Current Research Description

Circadian timing

Our lab is interested in characterizing the molecular and cellular events that underlie circadian (24 hr) rhythm generation, and how these rhythms modulate behavior and physiology.  Key research themes include:

• Molecular clock timing mechanisms
• Circadian entrainment mechanisms
• Mechanisms of cellular and systems-level circadian clock synchronization

Neuronal signaling and synaptic plasticity

Our lab is interested in understanding how brief bouts of synaptic communication are translated into long-term alterations in neuronal plasticity.  Issues related to cellular kinase pathways, inducible gene expression and neuronal morphology are of particular interest to us, as is understanding how these processes underlie complex behavioral processes, including learning and memory. Key research themes include:

• Calcium-activated kinase signaling
• CREB and synaptic physiology
• microRNA and synaptic plasticity

Circadian timing and disorders of the CNS 

We are interested in understanding how the disruption of clock timing contributes to neurodegeneration. Current studies of focused on the role of clock dysregulation in Alzheimer’s disease.